Tph2^tm2.2Pasq
Targeted Allele Detail

Summary

• Symbol: Tph2^tm2.2Pasq
• Name: tryptophan hydroxylase 2; targeted mutation 2.2, Massimo Pasqualetti
• MGI ID: MGI:5823173
• Synonyms: Tph2^null
• Gene: Tph2 Location: Chr10:114914546-115020927 bp, - strand Genetic Position: Chr10, 63.51 cM
• Alliance: Tph2^tm2.2Pasq page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238619
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette and left exon 3 floxed. Cre-mediated recombination removed exon 3. (J:238619)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tph2 Mutation: 43 strains or lines available

References

• Original: J:238619 Pelosi B, et al., Generation of a Tph2 Conditional Knockout Mouse Line for Time- and Tissue-Specific Depletion of Brain Serotonin. PLoS One. 2015;10(8):e0136422
• All: 1 reference(s)