Oprk1^tm2.1Kff
Targeted Allele Detail

Summary

• Symbol: Oprk1^tm2.1Kff
• Name: opioid receptor, kappa 1; targeted mutation 2.1, Brigitte L Kieffer
• MGI ID: MGI:5823257
• Synonyms: KOR^lox
• Gene: Oprk1 Location: Chr1:5658689-5676354 bp, + strand Genetic Position: Chr1, 1.89 cM, cytoband A2-A3
• Alliance: Oprk1^tm2.1Kff page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226396
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert a loxP-flanked hygromycin resistance (hygro) cassette upstream of exon 3 and a third loxP site downstream of exon 3. Transient transfection with a cre expression plasmid removed the loxP-flanked hygromycin cassette leaving exon 3 floxed. (J:226396)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Oprk1 Mutation: 30 strains or lines available

References

• Original: J:226396 Ehrich JM, et al., Kappa Opioid Receptor-Induced Aversion Requires p38 MAPK Activation in VTA Dopamine Neurons. J Neurosci. 2015 Sep 16;35(37):12917-31
• All: 7 reference(s)