Sgpp2^tm1Rlp
Targeted Allele Detail

Summary

• Symbol: Sgpp2^tm1Rlp
• Name: sphingosine-1-phosphate phosphatase 2; targeted mutation 1, Richard L Proia
• MGI ID: MGI:5823275
• Synonyms: Sgpp2^-
• Gene: Sgpp2 Location: Chr1:78286982-78396926 bp, + strand Genetic Position: Chr1, 40.23 cM
• Alliance: Sgpp2^tm1Rlp page

Sgpp2^tm1Rlp/Sgpp2^tm1Rlp mice showed normal skin appearance similar to wild-type mice, in contrast to severe ichtyosis in Sgpp1^{tm1(KOMP)Vlcg}/Sgpp1^{tm1(KOMP)Vlcg} mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:235035
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A neomycin selection cassette replaced a genomic fragment containing exons 3 and 4. Various tissues of homozygous mice failed to express detectable transcripts, as detected by semiquantitative real-time PCR. Total sphingosine-1-phosphate phosphatase (SPPase) enzymatic activity was decreased by ~30% in the membrane fraction from homozygous mutant lung tissue. (J:235035)

Generation of the Sgpp2^tm1Rlp allele

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sgpp2 Mutation: 14 strains or lines available

References

• Original: J:235035 Taguchi Y, et al., Sphingosine-1-phosphate Phosphatase 2 Regulates Pancreatic Islet beta-Cell Endoplasmic Reticulum Stress and Proliferation. J Biol Chem. 2016 Jun 3;291(23):12029-38
• All: 1 reference(s)