Zswim6^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Zswim6^em1(IMPC)J
• Name: zinc finger SWIM-type containing 6; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:5823481
• Synonyms: Zswim6^em1J
• Gene: Zswim6 Location: Chr13:107861152-108026598 bp, - strand Genetic Position: Chr13, 59.39 cM
• Alliance: Zswim6^em1(IMPC)J page
• IMPC: Zswim6 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele from project Zswim6-8179J-F8985 was generated at The Jackson Laboratory by injecting Cas9 RNA and 4 guide sequences CACTTTATACTAACTGAGAG, TTGACTTTCGGCAGCATAGG, AGTGAAGTGCAGCTTACTGT and GAGGCTCTGCTCTTTTAACA, which resulted in a 555 bp deletion beginning at Chromosome 13 negative strand position 107,773,763 bp, TTAACATGGAAGTACTTGGG, and ending after TAATTGACTTTCGGCAGCAT at 107,773,209 bp (GRCm38/mm10). This mutation deletes exon 4 and 406 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 338 and early truncation 23 amino acids later. (J:188991)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Zswim6 Mutation: 60 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 3 reference(s)