Tmco1^em1Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tmco1^em1Smoc
• Name: transmembrane and coiled-coil domains 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:5823562
• Synonyms: TMOC1 KO
• Gene: Tmco1 Location: Chr1:167136239-167161547 bp, + strand Genetic Position: Chr1, 74.69 cM
• Alliance: Tmco1^em1Smoc page

Mutation origin

• Strain of Origin: C57BL/6JSmoc

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: TALENs were designed to target exon 1 of the gene. Western blot analysis on mouse fibroblast lysates derived from homozygous mice showed that no detectable protein is expressed from this allele. (J:233671)

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tmco1 Mutation: 43 strains or lines available

References

• Original: J:233671 Wang QC, et al., TMCO1 Is an ER Ca(2+) Load-Activated Ca(2+) Channel. Cell. 2016 Jun 2;165(6):1454-66
• All: 5 reference(s)