Gt(ROSA)26Sor^tm1(JAG1)Xin
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^tm1(JAG1)Xin
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Li Xin
• MGI ID: MGI:5824048
• Synonyms: Gt(ROSA)26Sor^{tm1(JAG1,luc)Xin}, R26-LSL-JAG1
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^tm1(JAG1)Xin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238768
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^tm1(JAG1)Xin expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  JAG1 (182)

  Jag1	(MGI:1095416)

• Mutation details: The targeting vector was designed with (from 5' to 3') a loxP-flanked STOP cassette (neo with 3x polyA), jagged 1 (JAG1) human cDNA, and an internal ribosome entry site (IRES) fused to a luciferase sequence. This targeting vector was inserted between exons 1 and 2 of the Gt(ROSA)26Sor. (J:238768)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 994 strains or lines available

References

• Original: J:238768 Su Q, et al., Jagged1 upregulation in prostate epithelial cells promotes formation of reactive stroma in the Pten null mouse model for prostate cancer. Oncogene. 2017 Feb 02;36(5):618-627
• All: 3 reference(s)