Tg(Erbb2-Erbb2*V664E)#Led
Transgene Detail

Summary

• Symbol: Tg(Erbb2-Erbb2*V664E)#Led
• Name: transgene insertion, Philip Leder
• MGI ID: MGI:5824245
• Synonyms: TNT
• Transgene: Tg(Erbb2-Erbb2*V664E)#Led Location: unknown
• Alliance: Tg(Erbb2-Erbb2*V664E)#Led page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Erbb2-Erbb2*V664E)#Led expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Erbb2 (24337)

  Erbb2

  (MGI:95410)

  contains a V664E substition

• Mutation details: This transgene expresses a rat Erbb2 (neu) cDNA with a point mutation in the transmembrane domain resulting in a glutamate for valine substation at position 664 under the control of the mouse Erbb2 (neu) promoter. Multiple lines were generated. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:62441)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:62441 Weinstein EJ, et al., A mouse model for breast cancer induced by amplification and overexpression of the neu promoter and transgene. Mol Med. 2000 Jan;6(1):4-16
• All: 2 reference(s)