F12^tm1Fjc
Targeted Allele Detail

Summary

• Symbol: F12^tm1Fjc
• Name: coagulation factor XII (Hageman factor); targeted mutation 1, Francis J Castellino
• MGI ID: MGI:5824302
• Synonyms: FXII^-
• Gene: F12 Location: Chr13:55565771-55574606 bp, - strand Genetic Position: Chr13, 30.06 cM, cytoband B2
• Alliance: F12^tm1Fjc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238837
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The sequence encoding exons 3-8 was replaced with a neomycin resistance gene cassette, creating a null allele. (J:238837)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any F12 Mutation: 29 strains or lines available

References

• Original: J:238837 Iwaki T, et al., Plasma levels of bradykinin are suppressed in factor XII-deficient mice. Thromb Haemost. 2006 Jun;95(6):1003-10
• All: 4 reference(s)