Bloc1s2^tm1Wli
Targeted Allele Detail

Summary

• Symbol: Bloc1s2^tm1Wli
• Name: biogenesis of lysosomal organelles complex-1, subunit 2; targeted mutation 1, Wei Li
• MGI ID: MGI:5824713
• Synonyms: Bloc1s2^-, BLOS2-KO
• Gene: Bloc1s2 Location: Chr19:44127685-44134885 bp, - strand Genetic Position: Chr19, 36.72 cM, cytoband D1
• Alliance: Bloc1s2^tm1Wli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238623
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP-flanked PGK-neomycin selection cassette replaced exons 1-4 of the gene. Immunoblotting analysis showed that protein expression was absent in multiple tissues of homozygous mutant neonate mice, while the protein was highly expressed in the brain, spleen and intestine in control neonate mice. (J:238623)

Expression

In Mice Carrying this Mutation:	33 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bloc1s2 Mutation: 11 strains or lines available

References

• Original: J:238623 Zhou W, et al., BLOS2 negatively regulates Notch signaling during neural and hematopoietic stem and progenitor cell development. Elife. 2016 Oct 10;5:e18108
• All: 1 reference(s)