Pax9^{em1(cre/ERT2)Ychai}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pax9^{em1(cre/ERT2)Ychai}
• Name: paired box 9; endonuclease-mediated mutation 1, Yang Chai
• MGI ID: MGI:5824734
• Synonyms: Pax9-CreER
• Gene: Pax9 Location: Chr12:56738552-56759607 bp, + strand Genetic Position: Chr12, 24.53 cM
• Alliance: Pax9^{em1(cre/ERT2)Ychai} page

Mutation origin

• Strain of Origin: (C57BL/6 x DBA)F1

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Pax9^{em1(cre/ERT2)Ychai} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pax9 (MGI:97493)

• Mutation details: Plasmids encoding a signal guide RNA designed to introduce an E2A peptide cleavage site-cre/ERT2 into the last exon of the Pax9 gene (immediately before the stop codon) and the cas9 nuclease were introduced into the cytoplasm B6D2F1-derived fertilized eggs with well-recognized pronuclei. (J:236319)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pax9 (mouse) Summary of all recombinase alleles driven by Pax9. Alliance mouse Pax9 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pax9 Mutation: 17 strains or lines available

References

• Original: J:236319 Feng J, et al., Generation and characterization of tamoxifen-inducible Pax9-CreER knock-in mice using CrispR/Cas9. Genesis. 2016 Sep;54(9):490-6
• All: 2 reference(s)