Zbtb24^tm1Ldax
Targeted Allele Detail

Summary

• Symbol: Zbtb24^tm1Ldax
• Name: zinc finger and BTB domain containing 24; targeted mutation 1, Lucia Daxinger
• MGI ID: MGI:5824824
• Synonyms: Zbtb24^deltaBTB
• Gene: Zbtb24 Location: Chr10:41326379-41341570 bp, + strand Genetic Position: Chr10, 22.38 cM
• Alliance: Zbtb24^tm1Ldax page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238568
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin cassette in antisense orientation partially replaces the BTB-domain region, resulting in deletion of the last 15 bps of the non-coding exon 1 and the first 430 bps of exon 2, which encodes the BTB and AT-hook domains, and the first zinc finger motif. (J:238568)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zbtb24 Mutation: 39 strains or lines available

References

• Original: J:238568 Wu H, et al., Converging disease genes in ICF syndrome: ZBTB24 controls expression of CDCA7 in mammals. Hum Mol Genet. 2016 Sep 15;25(18):4041-4051
• All: 1 reference(s)