Slc6a8^tm1.1Lbar
Targeted Allele Detail

Summary

• Symbol: Slc6a8^tm1.1Lbar
• Name: solute carrier family 6 (neurotransmitter transporter, creatine), member 8; targeted mutation 1.1, Laura Baroncelli
• MGI ID: MGI:5825018
• Synonyms: Slc6a8^fl
• Gene: Slc6a8 Location: ChrX:72716756-72726108 bp, + strand Genetic Position: ChrX, 37.38 cM
• Alliance: Slc6a8^tm1.1Lbar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:232606
• Parent Cell Line: A8 (ES Cell)
• Strain of Origin: (C57BL/6 x 129P2/OlaHsd)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A conditional ready (floxed) allele was created by removing the FRT-flanked lacZ sequence, loxP site, neomycin cassette under the control of the human beta-actin promoter and SV40 polyA via flp-mediated recombination, and leaving exons 5-7 flanked by loxP sites. (J:232606)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc6a8 Mutation: 10 strains or lines available

Notes

ES cells used for allele generation: clone A8, gift fromA. Wutz, Wellcome Trust Centre for Stem Cell Research, Stem Cell Institute, University of Cambridge (J:232606).

References

• Original: J:232606 Baroncelli L, et al., A novel mouse model of creatine transporter deficiency. F1000Res. 2014;3:228
• All: 4 reference(s)