Slc6a8^tm1.2Lbar
Targeted Allele Detail

Summary

• Symbol: Slc6a8^tm1.2Lbar
• Name: solute carrier family 6 (neurotransmitter transporter, creatine), member 8; targeted mutation 1.2, Laura Baroncelli
• MGI ID: MGI:5825019
• Synonyms: CrT^-
• Gene: Slc6a8 Location: ChrX:72716756-72726108 bp, + strand Genetic Position: ChrX, 37.38 cM
• Alliance: Slc6a8^tm1.2Lbar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:232606
• Parent Cell Line: A8 (ES Cell)
• Strain of Origin: (C57BL/6 x 129P2/OlaHsd)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A reporter knock-out allele was generated via cre-mediated recombination which removed the floxed exons 5-7 and left an FRT site, followed by lacZ sequence and a loxP site upstream of the deleted exons. (J:232606)

Disease models

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc6a8 Mutation: 10 strains or lines available

Notes

ES cells used for allele generation: clone A8, gift fromA. Wutz, Wellcome Trust Centre for Stem Cell Research, Stem Cell Institute, University of Cambridge (J:232606).

References

• Original: J:232606 Baroncelli L, et al., A novel mouse model of creatine transporter deficiency. F1000Res. 2014;3:228
• All: 7 reference(s)