Lama3^tm1.1Grsb
Targeted Allele Detail

Summary

• Symbol: Lama3^tm1.1Grsb
• Name: laminin, alpha 3; targeted mutation 1.1, G R Scott Budinger
• MGI ID: MGI:5825195
• Synonyms: Lama3^fl
• Gene: Lama3 Location: Chr18:12466876-12716070 bp, + strand Genetic Position: Chr18, 6.2 cM, cytoband A
• Alliance: Lama3^tm1.1Grsb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:235712
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 42. A FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 42. Flp-mediated recombination removed the selection cassette and left exon 42 floxed. (J:235712)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lama3 Mutation: 192 strains or lines available

References

• Original: J:235712 Urich D, et al., Lung-specific loss of the laminin alpha3 subunit confers resistance to mechanical injury. J Cell Sci. 2011 Sep 1;124(Pt 17):2927-37
• All: 1 reference(s)