Pon3^tm1Dmsh
Targeted Allele Detail

Summary

• Symbol: Pon3^tm1Dmsh
• Name: paraoxonase 3; targeted mutation 1, Diana M Shih
• MGI ID: MGI:5825222
• Synonyms: Pon3KO
• Gene: Pon3 Location: Chr6:5220852-5256286 bp, - strand Genetic Position: Chr6, 1.99 cM
• Alliance: Pon3^tm1Dmsh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234615
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon 4. Western blot analysis confirmed the absence of protein expression in the liver. Lovastatinase activity is absent in liver homogenates of homozygous mutant mice, indicating complete loss of enzymatic activity. (J:234615)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pon3 Mutation: 24 strains or lines available

References

• Original: J:234615 Shih DM, et al., PON3 knockout mice are susceptible to obesity, gallstone formation, and atherosclerosis. FASEB J. 2015 Apr;29(4):1185-97
• All: 2 reference(s)