Ube3d^em1Xxl
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ube3d^em1Xxl
• Name: ubiquitin protein ligase E3D; endonuclease-mediated mutation 1, Xiao-Xin Li
• MGI ID: MGI:5825270
• Gene: Ube3d Location: Chr9:86189364-86347003 bp, - strand Genetic Position: Chr9, 46.58 cM, cytoband E3.2
• Alliance: Ube3d^em1Xxl page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas technology produced a 10 bp deletion in line ub-11. Western blot analysis confirmed reduced protein expression in heterozygotes. (J:233507)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ube3d Mutation: 20 strains or lines available

References

• Original: J:233507 Huang LZ, et al., Whole-exome sequencing implicates UBE3D in age-related macular degeneration in East Asian populations. Nat Commun. 2015;6:6687
• All: 2 reference(s)