Ncam2^tm1.1Bdrt
Targeted Allele Detail

Summary

• Symbol: Ncam2^tm1.1Bdrt
• Name: neural cell adhesion molecule 2; targeted mutation 1.1, Bernard Rothhut
• MGI ID: MGI:5825282
• Gene: Ncam2 Location: Chr16:80997585-81423716 bp, + strand Genetic Position: Chr16, 45.89 cM, cytoband C1-3
• Alliance: Ncam2^tm1.1Bdrt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:233502
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A MAPT-lacZ (tau-LacZ) fusion reporter followed by a floxed neomycin resistance cassette replaced the coding sequence of exon 1. Cre-mediated recombination removed the selection cassette. Immunofluorescence confirmed the absence of portein expression in spinal cord-derived neurospheres. (J:233502)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ncam2 Mutation: 87 strains or lines available

References

• Original: J:233502 Deleyrolle L, et al., OCAM regulates embryonic spinal cord stem cell proliferation by modulating ErbB2 receptor. PLoS One. 2015;10(4):e0122337
• All: 1 reference(s)