Swrl4^NZB
QTL Variant Detail

Summary

• QTL variant: Swrl4^NZB
• Name: SWR lupus locus 4; SWR
• MGI ID: MGI:5825285
• QTL: Swrl4 Location: unknown Genetic Position: Chr10, Syntenic

Variant origin

• Strain of Specimen: NZB

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:96263

Linkage analysis was performed on 88 animals from a SWR x (SWR x NZB)F1 backcross population to identify QTLs associated with lupus phenotypes. (SWR x NZB)F1 hybrid animals are susceptible to lupus nephritis. Animals were sero-typed at 9-12 months of age. 116 autosomal microsatellite markers at an average spacing of 10.6 cM were used for the genome scan.

Suggestive linkage to IgM or IgG anti-nuclear antibody (ANA) production mapped to 25 cM on mouse Chromosome 10 near D10Mit15 (LOD=2.11). This locus is tentatively named Swrl4 and also shows weak linkage to glomerulonephritis (LOD=1.1). SWR-derived alleles at Swrl4 confer increased IgM or IgG ANA production with a recessive mode of inheritance.

Suggestive linkage to early mortality mapped to 4 cM on mouse Chromosome 10 near D10Mit146 (LOD=2.17). NZB-derived alleles at D10Mit146 confer susceptibility to early mortality with a dominant mode of inheritance. A locus on distal mouse Chromosome 10 showed weak linkage to IgG3 antibody levels near D10Mit35a at74 cM (LOD=1.76). NZB-derived alleles at D10Mit35a confer increased IgG3 antibodies with a dominant mode of inheritance.

References

• Original: J:96263 Xie S, et al., Dominant NZB contributions to lupus in the (SWR x NZB)F1 model. Genes Immun. 2002 Oct;3 Suppl 1:S13-20
• All: 1 reference(s)