Trnau1ap^tm2.2Usch
Targeted Allele Detail

Summary

• Symbol: Trnau1ap^tm2.2Usch
• Name: tRNA selenocysteine 1 associated protein 1; targeted mutation 2.2, Ulrich Schweizer
• MGI ID: MGI:5825369
• Synonyms: Secp43^delta7,8
• Gene: Trnau1ap Location: Chr4:132039074-132056849 bp, - strand Genetic Position: Chr4, 65.16 cM, cytoband D3
• Alliance: Trnau1ap^tm2.2Usch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:237714
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 7. An FRT- and loxP-flanked neomycin resistance cassette were inserted downstream of exon 8. Flp-mediated recombination removed the selection cassette and left exons 7 and 8 floxed. Cre-mediated recombination removed exons 7 and 8. This mutation removes a portion of the Tyr-rich domain. (J:237714)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trnau1ap Mutation: 19 strains or lines available

References

• Original: J:237714 Mahdi Y, et al., Expression of Selenoproteins Is Maintained in Mice Carrying Mutations in SECp43, the tRNA Selenocysteine 1 Associated Protein (Trnau1ap). PLoS One. 2015;10(6):e0127349
• All: 1 reference(s)