Tg(MMTV-KRAS*G12V)3025Mrl
Transgene Detail

Summary

• Symbol: Tg(MMTV-KRAS*G12V)3025Mrl
• Name: transgene insertion 3025, Merck Research Laboratory
• MGI ID: MGI:5827748
• Synonyms: MMTV-Ki-rasB
• Transgene: Tg(MMTV-KRAS*G12V)3025Mrl Location: unknown
• Alliance: Tg(MMTV-KRAS*G12V)3025Mrl page

Transgene origin

• Strain of Origin: C57BL/6 x SJL

Transgene description

• Transgene Type: Transgenic (Constitutively active, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(MMTV-KRAS*G12V)3025Mrl expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  KRAS (3845)

  Kras	(MGI:96680)

  the G12V mutation renders KRAS constitutively active

• Mutation details: This transgene consists of the mouse mammary tumor virus long terminal repeat (MMTV LTR), 5'-untranslated region from the HaSv, sequences encoding oncogenically mutated (glycine to valine at codon 12) human Kirsten (Ki)-rasB, and SV40 polyadenylation sequence. Highest level of transgene expression is in mammary tissue and no expression is seen in the kidney, liver or spleen. (J:77272)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:77272 Omer CA, et al., Mouse mammary tumor virus-Ki-rasB transgenic mice develop mammary carcinomas that can be growth-inhibited by a farnesyl:protein transferase inhibitor. Cancer Res. 2000 May 15;60(10):2680-8
• All: 2 reference(s)