Prkcg^{tm2(cre/ERT2)Ddg}
Targeted Allele Detail

Summary

• Symbol: Prkcg^{tm2(cre/ERT2)Ddg}
• Name: protein kinase C, gamma; targeted mutation 2, David D Ginty
• MGI ID: MGI:5828137
• Synonyms: PKCgamma^CreERT2
• Gene: Prkcg Location: Chr7:3352038-3379615 bp, + strand Genetic Position: Chr7, 1.93 cM
• Alliance: Prkcg^{tm2(cre/ERT2)Ddg} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:239228
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Prkcg^{tm2(cre/ERT2)Ddg} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Prkcg (MGI:97597)

• Mutation details: A Cre recombinase-estrogen receptor T2 (CreERT2) fusion-FRT-Neomycin-FRT-loxP cassette was introduced into the first coding ATG of exon 1. (J:239228)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Prkcg (mouse) Summary of all recombinase alleles driven by Prkcg. Alliance mouse Prkcg gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prkcg Mutation: 42 strains or lines available

References

• Original: J:239228 Abraira VE, et al., The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn. Cell. 2017 Jan 12;168(1-2):295-310.e19
• All: 4 reference(s)