Tg(Fabp4-ENPP1)#Naba
Transgene Detail

Summary

• Symbol: Tg(Fabp4-ENPP1)#Naba
• Name: transgene insertion, Nicola Abate
• MGI ID: MGI:5828148
• Synonyms: AdiposeENPP1-Tg, AtENPP1-Tg
• Transgene: Tg(Fabp4-ENPP1)#Naba Location: unknown
• Alliance: Tg(Fabp4-ENPP1)#Naba page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Fabp4-ENPP1)#Naba expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ENPP1 (5167)

  Enpp1

  (MGI:97370)

• Mutation details: The human ENPP1 cDNA is under the control of the mouse aP2 promoter/enhancer. In addition a c-myc epitope tag was added to the amino terminus in the intracellular domain of ENPP1. Western blot analysis showed that protein level is elevated about 3-fold in white adipose tissue. (J:182179)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:182179 Pan W, et al., Metabolic consequences of ENPP1 overexpression in adipose tissue. Am J Physiol Endocrinol Metab. 2011 Nov;301(5):E901-11
• All: 2 reference(s)