Kdm1a^tm1Ebg
Targeted Allele Detail

Summary

• Symbol: Kdm1a^tm1Ebg
• Name: lysine (K)-specific demethylase 1A; targeted mutation 1, Elena Battaglioli
• MGI ID: MGI:5828154
• Synonyms: neuroLSD1^KO
• Gene: Kdm1a Location: Chr4:136277851-136330034 bp, - strand Genetic Position: Chr4, 68.8 cM
• Alliance: Kdm1a^tm1Ebg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:235553
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette replaced exon 8a, which is required for the neurospecific isoform. RT-PCR confirmed the lack of neurospecific isoform transcript in the hippocampus. (J:235553)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm1a Mutation: 39 strains or lines available

References

• Original: J:235553 Rusconi F, et al., LSD1 Neurospecific Alternative Splicing Controls Neuronal Excitability in Mouse Models of Epilepsy. Cereb Cortex. 2015 Sep;25(9):2729-40
• All: 3 reference(s)