Tg(SHBG)4-aGlha
Transgene Detail

Summary

• Symbol: Tg(SHBG)4-aGlha
• Name: transgene insertion 4-a, Geoffrey L Hammond
• MGI ID: MGI:5828513
• Synonyms: SHBG(4.3kb), shbg4-a
• Transgene: Tg(SHBG)4-aGlha Location: unknown
• Alliance: Tg(SHBG)4-aGlha page

Transgene origin

• Strain of Origin: (CBA x C57BL/6)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(SHBG)4-aGlha expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SHBG (6462)

  Shbg	(MGI:98295)

• Mutation details: This transgene consists of a 4.3-kb portion of human SHBG that comprises all eight exons plus 0.9 kb 5' of the translation initiation codon in exon 1 and 0.5 kb 3' from the polyadenylation sequence in exon 8. Three lines (4-a, 4-b, and 4-c) were generated. The transgene integrated as head to tail multimers with an estimated copy number of 11. (J:239368)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:239368 Janne M, et al., Human sex hormone-binding globulin gene expression in transgenic mice. Mol Endocrinol. 1998 Jan;12(1):123-36
• All: 9 reference(s)