Tg(CAG-cat,-Ptpn11*Q510E)#Krnz
Transgene Detail

Summary

• Symbol: Tg(CAG-cat,-Ptpn11*Q510E)#Krnz
• Name: transgene insertion, Maike Krenz
• MGI ID: MGI:5828597
• Synonyms: CC-Q510E
• Transgene: Tg(CAG-cat,-Ptpn11*Q510E)#Krnz Location: unknown
• Alliance: Tg(CAG-cat,-Ptpn11*Q510E)#Krnz page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-cat,-Ptpn11*Q510E)#Krnz expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Ptpn11

• Mutation details: The CAG (cytomegalovirus enhancer and chicken beta-actin) promoter was used to drive cre-dependent expression of a modified Ptpn11 gene, which contains the amino acid substitution of glutamate for glutamine at position 510, following removal of an intervening floxed chloramphenicol acetyltransferase (cat) gene. The Q510E mutation is found in patients with aggressive Noonan syndrome with multiple lentigines. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:237450)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:237450 Edwards MA, et al., The Q510E mutation in Shp2 perturbs heart valve development by increasing cell migration. J Appl Physiol (1985). 2015 Jan 1;118(1):124-31
• All: 1 reference(s)