Setd7^tm1.1Ital
Targeted Allele Detail

Summary

• Symbol: Setd7^tm1.1Ital
• Name: SET domain containing (lysine methyltransferase) 7; targeted mutation 1.1, Iannis Talianidis
• MGI ID: MGI:5828599
• Synonyms: Set9-KO
• Gene: Setd7 Location: Chr3:51422740-51468300 bp, - strand Genetic Position: Chr3, 22.5 cM
• Alliance: Setd7^tm1.1Ital page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238299
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 4. A floxed neomycin resistance cassette was inserted downstream of exon 4. Cre-mediated recombination removed exon 4 and the selection cassette. Western blot analysis confirmed the absence of protein expression in lung fibroblasts. (J:238299)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Setd7 Mutation: 29 strains or lines available

References

• Original: J:238299 Elkouris M, et al., SET9-Mediated Regulation of TGF-beta Signaling Links Protein Methylation to Pulmonary Fibrosis. Cell Rep. 2016 Jun 21;15(12):2733-44
• All: 1 reference(s)