Fgfr1^tm7.1Sor
Targeted Allele Detail

Summary

• Symbol: Fgfr1^tm7.1Sor
• Name: fibroblast growth factor receptor 1; targeted mutation 7.1, Philippe Soriano
• MGI ID: MGI:5828620
• Synonyms: Fgfr1^C
• Gene: Fgfr1 Location: Chr8:26008808-26067819 bp, + strand Genetic Position: Chr8, 14.12 cM
• Alliance: Fgfr1^tm7.1Sor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226497
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 10 was replaced with one in which nucleotide substitutions result in a silent mutation and the amino acid substitution of phenylalanine for tyrosine at position 463 (Y463F). Cre-mediated recombination removed the floxed neomycin resistance cassette inserted in intron 9. (J:226497)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgfr1 Mutation: 223 strains or lines available

References

• Original: J:226497 Brewer JR, et al., Fgfr1 regulates development through the combinatorial use of signaling proteins. Genes Dev. 2015 Sep 1;29(17):1863-74
• All: 2 reference(s)