Fgfr1^tm10.1Sor
Targeted Allele Detail

Summary

• Symbol: Fgfr1^tm10.1Sor
• Name: fibroblast growth factor receptor 1; targeted mutation 10.1, Philippe Soriano
• MGI ID: MGI:5828624
• Synonyms: Fgfr1^FCPG
• Gene: Fgfr1 Location: Chr8:26008808-26067819 bp, + strand Genetic Position: Chr8, 14.12 cM
• Alliance: Fgfr1^tm10.1Sor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226497
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 9 was replaced with a modified one in which nucleotide substitutions result in silent mutations and the amino acid substitution of alanine for leucine at position 423 (L423A). Exon 10 was replaced with one in which nucleotide substitutions result in a silent mutation and the amino acid substitution of alanine for valine at position 429 (V429A) and phenylalanine for tyrosine at position 463 (Y463F). Exon 18 was replaced with one in which nucleotide substitutions result in the amino acid substitution of phenylalanine for tyrosine at positions 766 and 776 (Y766F, Y776F). Cre-mediated recombination removed the floxed neomycin resistance cassette inserted in intron 9. (J:226497)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fgfr1 Mutation: 223 strains or lines available

References

• Original: J:226497 Brewer JR, et al., Fgfr1 regulates development through the combinatorial use of signaling proteins. Genes Dev. 2015 Sep 1;29(17):1863-74
• All: 3 reference(s)