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Tg(Thy1-UBQLN2)356Mont
Transgene Detail
Summary
Symbol: Tg(Thy1-UBQLN2)356Mont
Name: transgene insertion 356, Mervyn Monteiro
MGI ID: MGI:5829042
Synonyms: UBQLN2 WT
Transgene: Tg(Thy1-UBQLN2)356Mont  Location: unknown  
Alliance: Tg(Thy1-UBQLN2)356Mont page
Transgene
origin
Strain of Origin:  SJL or C57BL/6J
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Thy1-UBQLN2)356Mont expresses 1 gene
 
Mutation detailsThe transgene was designed to have the modified ~6.5 kbp mouse Thy1.2 promoter (Thy1 sequences extending from the promoter to the intron following exon 4, excluding exon 3 and its flanking introns) followed by a cDNA sequence encoding the full-length, wildtype human ubiquilin 2 protein. UBQLN2 missense mutations are linked to dominant inheritance of amyotrophic lateral sclerosis (ALS) with frontotemporal dementia (FTD). Founder line 356 was found to have ~1.5-3.5 copies of the transgene. (J:239510)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
The transgenic construct was injected into fertilized SJL/C57BL/6J hybrid eggs per the primary investigator.
References
Original:  J:239510 Le NT, et al., Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS-FTD-linked UBQLN2 mutations. Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7580-E7589
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory