Rr39^em1Ched
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rr39^em1Ched
• Name: regulatory region 39; endonuclease-mediated mutation 1, Catherine Hedrick
• MGI ID: MGI:5829195
• Synonyms: Nr4a1se_2^-
• Gene: Rr39 Location: Chr15:101160047-101161625 bp
• Alliance: Rr39^em1Ched page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutation: Intergenic deletion
• Mutation details: A 1500 bp deletion was introduced by CRISPR/cas9 endonuclease mediated genome editing 4 kb upstream of the Nr4a1 transcription start site in the Nr4a1 super enhancer (se) sub-domain E2. The deletion spans 101,262,166-101,263,744 (GRCm38/mm10). Nr4a1 gene expression is not altered. (J:239509)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rr39 Mutation: 1 strain or line available

References

• Original: J:239509 Thomas GD, et al., Deleting an Nr4a1 Super-Enhancer Subdomain Ablates Ly6Clow Monocytes while Preserving Macrophage Gene Function. Immunity. 2016 Nov 15;45(5):975-987
• All: 4 reference(s)