Asxl2^tm1.1Oaw
Targeted Allele Detail

Summary

• Symbol: Asxl2^tm1.1Oaw
• Name: ASXL transcriptional regulator 2; targeted mutation 1.1, Omar Abdel-Wahab
• MGI ID: MGI:5829437
• Synonyms: Asxl2^fl
• Gene: Asxl2 Location: Chr12:3476857-3556852 bp, + strand Genetic Position: Chr12, 1.81 cM
• Alliance: Asxl2^tm1.1Oaw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:249948
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert an FRT-loxP-neomycin cassette-FRT-loxP upstream of exon 11, and a loxP downstream of exon 11. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 11 floxed. (J:249948)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Asxl2 Mutation: 126 strains or lines available

References

• Original: J:249948 Micol JB, et al., ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia. Nat Commun. 2017 May 18;8:15429
• All: 1 reference(s)