Tert^tm1.1Phan
Targeted Allele Detail

Summary

• Symbol: Tert^tm1.1Phan
• Name: telomerase reverse transcriptase; targeted mutation 1.1, Sem Phan
• MGI ID: MGI:5829569
• Synonyms: floxed TERT, TERT^fl
• Gene: Tert Location: Chr13:73775030-73797962 bp, + strand Genetic Position: Chr13, 40.12 cM
• Alliance: Tert^tm1.1Phan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:239734
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert a loxP site upstream of exon 1, including 1.5 kb of the promoter sequence, and an FRT-flanked neomycin resistance cassette, followed by a second loxP site, downstream of exon 2. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exons 1 and 2 floxed. (J:239734)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tert Mutation: 53 strains or lines available

References

• Original: J:239734 Liu T, et al., Conditional Knockout of Telomerase Reverse Transcriptase in Mesenchymal Cells Impairs Mouse Pulmonary Fibrosis. PLoS One. 2015;10(11):e0142547
• All: 4 reference(s)