Klf14^tm1.1Yec
Targeted Allele Detail

Summary

• Symbol: Klf14^tm1.1Yec
• Name: Kruppel-like transcription factor 14; targeted mutation 1.1, Yuqing E Chen
• MGI ID: MGI:5882062
• Synonyms: Klf14^fl
• Gene: Klf14 Location: Chr6:30932956-30935925 bp, - strand Genetic Position: Chr6, 12.54 cM
• Alliance: Klf14^tm1.1Yec page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226403
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted upstream of the coding sequence. An F3-flanked puromycin resistance cassette with a 5' loxP site was inserted downstream of the coding exon. Flp-mediated recombination removed the selection cassettes and left the coding sequence floxed. (J:226403)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klf14 Mutation: 23 strains or lines available

References

• Original: J:226403 Guo Y, et al., Perhexiline activates KLF14 and reduces atherosclerosis by modulating ApoA-I production. J Clin Invest. 2015 Oct 1;125(10):3819-30
• All: 3 reference(s)