Aggf1^tm1Qkw
Targeted Allele Detail

Summary

• Symbol: Aggf1^tm1Qkw
• Name: angiogenic factor with G patch and FHA domains 1; targeted mutation 1, Qing Kenneth Wang
• MGI ID: MGI:5882327
• Gene: Aggf1 Location: Chr13:95487191-95511860 bp, - strand Genetic Position: Chr13, 49.41 cM
• Alliance: Aggf1^tm1Qkw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:239252
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129 and C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin-resistance gene replaced exons 2-11 via homologous recombination. (J:239252)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aggf1 Mutation: 36 strains or lines available

References

• Original: J:239252 Zhang T, et al., Haploinsufficiency of Klippel-Trenaunay syndrome gene Aggf1 inhibits developmental and pathological angiogenesis by inactivating PI3K and AKT and disrupts vascular integrity by activating VE-cadherin. Hum Mol Genet. 2016 Dec 1;25(23):5094-5110
• All: 3 reference(s)