Tg(EmuSR-HDAC9)1468Kpet
Transgene Detail

Summary

• Symbol: Tg(EmuSR-HDAC9)1468Kpet
• Name: transgene insertion 1468, Kevin Petrie
• MGI ID: MGI:5882421
• Synonyms: HDAC9^TG
• Transgene: Tg(EmuSR-HDAC9)1468Kpet Location: unknown
• Alliance: Tg(EmuSR-HDAC9)1468Kpet page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(EmuSR-HDAC9)1468Kpet expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HDAC9 (9734)

  Hdac9

  (MGI:1931221)

• Mutation details: A FLAG-epitope-tagged full-length human HDAC9 cDNA is under the control of the immunoglobulin heavy chain (IgH) enhancer (Emu) and the SRalpha potent promoter. Three lines (1468, 1469, and 1839) were generated. Line 1468 was entered as a representative line as this line has the highest lymphoma prevalence. The transgene is expressed in the bone marrow and spleen but not in the liver. (J:237420)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:237420 Gil VS, et al., Deregulated expression of HDAC9 in B cells promotes development of lymphoproliferative disease and lymphoma in mice. Dis Model Mech. 2016 Dec 01;9(12):1483-1495
• All: 1 reference(s)