Plaat3^tm1.1Hsul
Targeted Allele Detail

Summary

• Symbol: Plaat3^tm1.1Hsul
• Name: phospholipase A and acyltransferase 3; targeted mutation 1.1, Hei Sul
• MGI ID: MGI:5882500
• Gene: Plaat3 Location: Chr19:7534824-7565910 bp, + strand Genetic Position: Chr19, 5.33 cM
• Alliance: Plaat3^tm1.1Hsul page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:239202
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 3. Cre-mediated recombination removed the selection cassette and exon 3. Western blot analysis confirmed the absence of protein expression in epididymal and renal white adipose tissue. (J:239202)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plaat3 Mutation: 43 strains or lines available

References

• Original: J:239202 Jaworski K, et al., AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency. Nat Med. 2009 Feb;15(2):159-68
• All: 1 reference(s)