Krt36^tm1Hpt
Targeted Allele Detail

Summary

• Symbol: Krt36^tm1Hpt
• Name: keratin 36; targeted mutation 1, Heiko Peters
• MGI ID: MGI:5882518
• Gene: Krt36 Location: Chr11:99992833-99996452 bp, - strand Genetic Position: Chr11, 63.41 cM, cytoband D
• Alliance: Krt36^tm1Hpt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82809
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP-flanked neomycin selection cassette has replaced exons 1-3. No Krt36 mRNA is detectable in homozygous mutant mice retaining the cassette. (J:82809)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Krt36 Mutation: 35 strains or lines available

Notes

Crossing these mice to animals expressing Cre recombinase is not recommended because Cre-mediated recombination results in production of a hybrid keratin mRNA (presumably involving another, closely linked keratin gene), a partially functional protein, and a milder homozygous (hypomorphic) phenotype. (J:82809)

References

• Original: J:82809 European Mouse Mutant Archive, Information obtained from the European Mouse Mutant Archive (EMMA). Unpublished. 2003-2013
• All: 1 reference(s)