Map3k3^tm1.1Mlkn
Targeted Allele Detail

Summary

• Symbol: Map3k3^tm1.1Mlkn
• Name: mitogen-activated protein kinase kinase kinase 3; targeted mutation 1.1, Mark Kahn
• MGI ID: MGI:5882560
• Synonyms: Map3k3^fl
• Gene: Map3k3 Location: Chr11:105975439-106046272 bp, + strand Genetic Position: Chr11, 68.89 cM
• Alliance: Map3k3^tm1.1Mlkn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238897
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 9. An F3-flanked puromycin resistance cassette with a 3' loxP site was inserted downstream of exon 15. Flp-mediated recombination removed the selection cassette and left exons 9 through 15 floxed. (J:238897)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map3k3 Mutation: 27 strains or lines available

Notes

ES cell line = Art B6.3.5 (C57BL/6NTac)

References

• Original: J:238897 Zhou Z, et al., The cerebral cavernous malformation pathway controls cardiac development via regulation of endocardial MEKK3 signaling and KLF expression. Dev Cell. 2015 Jan 26;32(2):168-80
• All: 3 reference(s)