Tg(Col1a1-Ifitm5*)1Brle
Transgene Detail

Summary

• Symbol: Tg(Col1a1-Ifitm5*)1Brle
• Name: transgene insertion 1, Brendan Lee
• MGI ID: MGI:5882591
• Transgene: Tg(Col1a1-Ifitm5*)1Brle Location: unknown
• Alliance: Tg(Col1a1-Ifitm5*)1Brle page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Col1a1-Ifitm5*)1Brle expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ifitm5 (MGI:1934923)	Expresses murine Ifitm5 with the corresponding human c.-14C-T mutation

• Mutation details: The murine Ifitm5 cDNA with the corresponding human c.-14C-T mutation is under the control of the osteoblast specific Col1a1 2.3-kb promoter. The tyrosinase minigene is included for identification of transgenics. Three lines were generated: 1, 2, and 3. (J:233366)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:233366 Lietman CD, et al., A transgenic mouse model of OI type V supports a neomorphic mechanism of the IFITM5 mutation. J Bone Miner Res. 2015 Mar;30(3):489-98
• All: 1 reference(s)