Clcn7^tm1.1Mawa
Targeted Allele Detail

Summary

• Symbol: Clcn7^tm1.1Mawa
• Name: chloride channel, voltage-sensitive 7; targeted mutation 1.1, Matthew Warman
• MGI ID: MGI:5882799
• Synonyms: Clcn7^F318L
• Gene: Clcn7 Location: Chr17:25352365-25381078 bp, + strand Genetic Position: Chr17, 12.53 cM, cytoband A3.3
• Alliance: Clcn7^tm1.1Mawa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: An F316L (CTT->CCT) missense mutation (corresponding to the human F318L mutation) and loxP-flanked neomycin cassette are introduced to exon 11 of the gene via homologous recombination. Cre-mediated recombination removed the floxed neo cassette. (J:101977)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Clcn7 Mutation: 42 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 2 reference(s)