Agtr1a^tm3Tma
Targeted Allele Detail

Summary

• Symbol: Agtr1a^tm3Tma
• Name: angiotensin II receptor, type 1a; targeted mutation 3, Taiji Matsusaka
• MGI ID: MGI:5883021
• Synonyms: Agtra1^loxP
• Gene: Agtr1a Location: Chr13:30520424-30566850 bp, + strand Genetic Position: Chr13, 13.19 cM
• Alliance: Agtr1a^tm3Tma page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240316
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A single loxP site into intron 2 upstream of exon 3, and an loxP-flanked neo cassette into intron 3 were inserted via homologous recombination in ES cells. The PGK-neo cassette was removed by transient transfection of cre expressing plasmid prior to introduction into blastcyst. (J:240316)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Agtr1a Mutation: 40 strains or lines available

References

• Original: J:240316 Matsusaka T, et al., Angiotensin receptor blocker protection against podocyte-induced sclerosis is podocyte angiotensin II type 1 receptor-independent. Hypertension. 2010 Apr;55(4):967-73
• All: 2 reference(s)