Otog^vbd
Chemically induced Allele Detail

Summary

• Symbol: Otog^vbd
• Name: otogelin; vestibular balance defect
• MGI ID: MGI:5883222
• Gene: Otog Location: Chr7:45890411-45960858 bp, + strand Genetic Position: Chr7, 29.66 cM, cytoband B4-C
• Alliance: Otog^vbd page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: This ENU-induced mutation was isolated in the Munich genome wide ENU recessive mutagenesis program. Gene mapping identified a one base pair substitution, a T36351 to C36351 transition at the splice donor site of intron 29, leading to a frame-shift of translation inducing an addition of 16 new amino acids at the carboxyl-terminus and a premature stop codon. (J:234038)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Otog Mutation: 149 strains or lines available

References

• Original: J:234038 El Hakam Kamareddin C, et al., A new Otogelin ENU mouse model for autosomal-recessive nonsyndromic moderate hearing impairment. Springerplus. 2015;4:730
• All: 2 reference(s)