Tg(MMTV-ERBB2*)#Arbs
Transgene Detail

Summary

• Symbol: Tg(MMTV-ERBB2*)#Arbs
• Name: transgene insertion, Joaquin Arribas
• MGI ID: MGI:5883855
• Synonyms: HER2M687, TG 687, Tg(MMTV-Erbb2)
• Transgene: Tg(MMTV-ERBB2*)#Arbs Location: unknown
• Alliance: Tg(MMTV-ERBB2*)#Arbs page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(MMTV-ERBB2*)#Arbs expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ERBB2 (2064)

  Erbb2

  (MGI:95410)

  expresses a C-terminal fragment from Met 687

• Mutation details: This transgene expresses a C-terminal fragment (CTF) of the human erb-b2 receptor tyrosine kinase 2 (ERBB2; also called HER2 or Neu) protein transcribed from the methionine codon at position 687 of the cDNA (GenBank Accession M11730.1; GI:183986) under control of the Rous sarcoma virus enhancer followed by the mouse mammary tumor virus (MMTV) long terminal repeat. Western blot analysis of mammary gland lysates from 7 week-old homozygous transgenic mice using antibodies to the cytoplasmic domain of ERBB2 demonstrated expression of the CTF at 0.5-fold and 2-fold the level of endogenous ERBB2 in transgenic mouse lines F1 and F2, respectively. "#" is used in place of a line number in the transgene symbol because the line number of the distributed strain is not specified. (J:149905)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:149905 Pedersen K, et al., A naturally occurring HER2 carboxy-terminal fragment promotes mammary tumor growth and metastasis. Mol Cell Biol. 2009 Jun;29(12):3319-31
• All: 2 reference(s)