Fgfbp1^tm1Gvdz
Targeted Allele Detail

Summary

• Symbol: Fgfbp1^tm1Gvdz
• Name: fibroblast growth factor binding protein 1; targeted mutation 1, Gregorio Valdez
• MGI ID: MGI:5888855
• Gene: Fgfbp1 Location: Chr5:44136200-44139121 bp, - strand Genetic Position: Chr5, 23.95 cM
• Alliance: Fgfbp1^tm1Gvdz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:237911
• Parent Cell Line: Lex-2 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Homologous recombination resulted in the deletion of the entire coding region of the gene and replacement with an IRES-beta-galactosidase/Neomycin fusion (BetaGeo) selection cassette. Transcripts were completely absent from the TA muscle of homozygous mutant mice. (J:237911)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgfbp1 Mutation: 19 strains or lines available

References

• Original: J:237911 Taetzsch T, et al., Muscle Fibers Secrete FGFBP1 to Slow Degeneration of Neuromuscular Synapses during Aging and Progression of ALS. J Neurosci. 2017 Jan 04;37(1):70-82
• All: 1 reference(s)