Spdya^tm1.1Klad
Targeted Allele Detail

Summary

• Symbol: Spdya^tm1.1Klad
• Name: speedy/RINGO cell cycle regulator family, member A; targeted mutation 1.1, Phillip Kladis
• MGI ID: MGI:5888863
• Synonyms: Spdya^-, Spdya^tm1.1Kliu
• Gene: Spdya Location: Chr17:71859056-71896528 bp, + strand Genetic Position: Chr17, 41.87 cM, cytoband E2
• Alliance: Spdya^tm1.1Klad page

Depletion of male and female germ cells in Spdya^tm1.1Klad/Spdya^tm1.1Klad mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:239544
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was was targeted and flanked by a loxP site at its 5' end and a FRT-Neo-FRT-loxP cassette at its 3'end. Subsequent cre-mediated recombination resulted in the deletion of loxP-flanked sequences. (J:239544)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spdya Mutation: 12 strains or lines available

References

• Original: J:239544 Tu Z, et al., Speedy A-Cdk2 binding mediates initial telomere-nuclear envelope attachment during meiotic prophase I independent of Cdk2 activation. Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):592-597
• All: 3 reference(s)