Nradd^tm1.2Pabk
Targeted Allele Detail

Summary

• Symbol: Nradd^tm1.2Pabk
• Name: neurotrophin receptor associated death domain; targeted mutation 1.2, Philip A Barker
• MGI ID: MGI:5888871
• Synonyms: Nradd^-, NRH2^-
• Gene: Nradd Location: Chr9:110450203-110453461 bp, - strand Genetic Position: Chr9, 60.26 cM, cytoband F2
• Alliance: Nradd^tm1.2Pabk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:237623
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Null/knockout) Mutation: Intragenic deletion Mutation details: LoxP sites were inserted to flank exon 2. A frt-flanked neomycin selection cassette was removed via Flp-mediated recombination, and subsequent Cre-mediated recombination deleted exon 2 to generate the null allele. Western blot analysis confirmed the absence of protein expression in spleen tissue of adult homozygous mutant mice. (J:237623)

Generation of the Nradd^tm1.1Pabk and Nradd^tm1.2Pabk alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nradd Mutation: 24 strains or lines available

References

• Original: J:237623 Unsain N, et al., Generation and characterization of mice bearing null alleles of nradd/Nrh2. Genesis. 2016 Dec;54(12):605-612
• All: 1 reference(s)