Slc39a7^tm1.1Tfk
Targeted Allele Detail

Summary

• Symbol: Slc39a7^tm1.1Tfk
• Name: solute carrier family 39 (zinc transporter), member 7; targeted mutation 1, Toshiyuki Fukada
• MGI ID: MGI:5888872
• Synonyms: Zip7^flox
• Gene: Slc39a7 Location: Chr17:34247243-34250656 bp, - strand Genetic Position: Chr17, 17.98 cM
• Alliance: Slc39a7^tm1.1Tfk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236234
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a loxP sequence and a neo cassette into the region between exons 4 and 5, and a loxP sequence between exons 6 and 7 of the gene. Subsequent cre-mediated recombination to remove the neo cassette resulted in exons 5 and 6 flanked by loxP sites. (J:236234)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc39a7 Mutation: 29 strains or lines available

References

• Original: J:236234 Ohashi W, et al., Zinc Transporter SLC39A7/ZIP7 Promotes Intestinal Epithelial Self-Renewal by Resolving ER Stress. PLoS Genet. 2016 Oct;12(10):e1006349
• All: 2 reference(s)