Fgf3^tm1Lwd
Targeted Allele Detail

Summary

• Symbol: Fgf3^tm1Lwd
• Name: fibroblast growth factor 3; targeted mutation 1, Mark Lewandoski
• MGI ID: MGI:5888884
• Synonyms: Fgf^delta
• Gene: Fgf3 Location: Chr7:144392349-144397085 bp, + strand Genetic Position: Chr7, 88.85 cM
• Alliance: Fgf3^tm1Lwd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229949
• Parent Cell Line: v6.4 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A hygromycin B cassette is used to replace the coding region, starting 261 bp upstraim of the start codon and ending downstream of the stop codon (5810 bp total). (J:229949)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fgf3 Mutation: 16 strains or lines available

Notes

This mutation was generated by re-targeting v6.4 ES cells in which Fgf4 had been targeted to create Fgf4^tm1.1Lwd. Both mutations were determined to be in cis on the 129 chromosome and are tightly linked. (J:229949)

References

• Original: J:229949 Anderson MJ, et al., Fgf3-Fgf4-cis: A new mouse line for studying Fgf functions during mouse development. Genesis. 2016 Feb;54(2):91-8
• All: 2 reference(s)