Ntn1^tm1.2Good
Targeted Allele Detail

Summary

• Symbol: Ntn1^tm1.2Good
• Name: netrin 1; targeted mutation 1.2, Lisa Goodrich
• MGI ID: MGI:5888901
• Synonyms: Ntn1^-
• Gene: Ntn1 Location: Chr11:68100190-68277652 bp, - strand Genetic Position: Chr11, 41.45 cM, cytoband B3
• Alliance: Ntn1^tm1.2Good page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226697
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was floxed. Flp-mediated recombination removed the frt-flanked neomycin resistance cassette inserted downstream of exon 2. Cre-mediated recombination removed exon 2. Western blot analysis confirmed the absence of protein expression on E11.5 head lysates. (J:226697)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ntn1 Mutation: 107 strains or lines available

References

• Original: J:226697 Yung AR, et al., Phenotypic analysis of mice completely lacking netrin 1. Development. 2015 Nov 1;142(21):3686-91
• All: 5 reference(s)