Fgf4^tm1.2Lwd
Targeted Allele Detail

Summary

• Symbol: Fgf4^tm1.2Lwd
• Name: fibroblast growth factor 4; targeted mutation 1.2, Mark Lewandoski
• MGI ID: MGI:5888998
• Synonyms: Fgf4^delta
• Gene: Fgf4 Location: Chr7:144415123-144418982 bp, + strand Genetic Position: Chr7, 88.88 cM
• Alliance: Fgf4^tm1.2Lwd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229949
• Parent Cell Line: v6.4 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A targeting vector is used to insert a loxP site and an FRT-site flanked PGK-NEO cassette into intron 1 followed by a second loxP site downstream of exon 3. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exons 2 and 3 floxed. Cre-mediated recombination removed the exons 2 and 3. (J:229949)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgf4 Mutation: 30 strains or lines available

References

• Original: J:229949 Anderson MJ, et al., Fgf3-Fgf4-cis: A new mouse line for studying Fgf functions during mouse development. Genesis. 2016 Feb;54(2):91-8
• All: 2 reference(s)